RNAi data were available for 14 out of these 19 genes and in all cases gene silencing led to increased proliferation in at least one ovarian cancer cell line and the block of eight genes (KDM5B, TIAM1, RAGEF2, PRKCQ, VAV1, PTPRG, RBL2 and MCM4) favoured cell growth in the majority of cell lines (Figure 4D). The gene discussed is RAPGEF6; the disease is ovarian cancer.