KIAA1549 and central nervous system cancer: Additionally, a recent abstract suggests that in glioma cell lines engineered to express the KIAA1549:BRAF fusion, there is resistance to therapy with BRAF V600E inhibitors, and in fact, the paradoxical growth activation (previously only seen in wild-type BRAF cells treated with BRAF V600E inhibitors) is observed (Lang et al., 2012).