AKT1 and pilocytic astrocytoma: Also, in a molecular analysis study of 92 pilocytic astrocytomas including 43 conventional pilocytic astrocytomas, 25 clinically aggressive/recurrent pilocytic astrocytomas, and 25 anaplastic pilocytic astrocytomas, an increase in cytoplasmic phosphorylated-Akt (phospho-Akt) and phospho-S6 was associated with anaplastic histology (a more aggressive phenotype) and poorer outcomes in pilocytic astrocytomas (Rodriguez et al., 2011).