In murine xenografts of a pilocytic astrocytoma with mutated BRAF V600E, treatment with PLX4720 + everolimus led to a statistically significant survival advantage, when compared to treatment with vehicle alone (p = 0.0002), PLX4720 alone (p = 0.0126), or everolimus alone (p = 0.0031). The gene discussed is BRAF; the disease is pilocytic astrocytoma.