Transgelin has also been reported to play a role in tumor suppression in certain cells by interfering with ERK activation and AP-1 signaling to decrease the expression of MMP-9, which is extremely involved in invasiveness of cancer [57].NDRG1 (N-Myc downstream regulated gene 1), is localized in the nucleus, cytoplasm, cell membrane, and intracellular organelles [58]. This evidence concerns the gene MMP9 and cancer.