The group of genes isolated in more than one survival screen (Table S1) included B2M (found in the glioblastoma and melanoma libraries), MALAT1 (identified in the melanoma and leukemia libraries, in both cases exclusively with the CED4-expressing HC4 yeast strain) and SPCS2 (found in the melanoma and leukemia libraries). This evidence concerns the gene APAF1 and melanoma.