NR3C1 and cancer: GR is down-regulated in response to GC exposure in most tissues [20]–[23] and in some tissues down-regulation is linked to aging [24], [25], exercise [24] and psychological stress [26], [27], while up-regulation in some tissues is linked to HIV infection [28], muscle sepsis [9], dietary restriction [29], adrenalectomy [30] and cancer [10].