Although the roles of WNT-antagonists (such as secreted frizzled related proteins (SFRPs)), DNA methyltransferases (DNMT) and histone deacetylation in human colonic carcinogenesis are well documented, the expression of DNMT1, SFRR5 and acetylation of histone H3 in this model are largely unknown; which play crucial roles in the development and progression of human colon cancers [33]–[35]. The gene discussed is DNMT1; the disease is malignant colon neoplasm.