DNMT1 and infectious otitis media: Strong nuclear staining of DNMT1 and less intense nuclear staining of Ac-H3 were noted in AOM-induced tumors (Figure 3B); relative to normal crypt (Figure 3A) and normal-appearing crypts (Figure 3B), where DNMT1 and AC-H3 positive cells were predominantly located in proliferative compartment (Figure 3B).