The percentage of cells showing Ki-67 nuclear staining was reduced in a similar pattern by Se alone (P<0.05) and the combination diet (P<0.01), green tea alone did not affect cell proliferation (Figure 2B and 2D), with a low level of Ki-67 staining in AOM-untreated normal crypts (Figure 2A). Here, MKI67 is linked to infectious otitis media.