SFRP2 and colonic neoplasm: It has been shown that genistein attenuates the WNT signaling by up-regulating SFRP2 in a human colon cancer cells through changes in demethylation of CpG islands of SFRP2 promoter region [57], and the anthocyanins derived from black raspberries demethylates tumor suppressor genes of SFRP2, 5 and WIF1 through inhibition of DNMT1 and DNMT3B [58].