Furthermore, higher expression of known oncogenes such as Bcl-2, Bcl-3, Bcl-6, Ets1, Ets2, Fos, Fosb, Jun, Junb and Kit was also noted in Runx1−/− cells (Table S1 and Refs therein, and Figure 2F and G), consistent with the increased proliferation of FL-MKRunx1−/− and the predisposition to leukemia in humans with RUNX1 deficiency. This evidence concerns the gene RUNX1 and leukemia.