Using target prediction algorithms, including TargetScan, [18]–[20], it emerges that these miRNAs may target genes of known importance in GIST cell biology including KIT, PDGFRA IGF1R, NF1, MAPK1, SDH and KRAS[9], [14], [28], however further investigation is required to confirm this as well as other potentially important gene targets. This evidence concerns the gene IGF1R and gastrointestinal stromal tumor.