Our results are different from the ones described by Grosser et al.[33] who showed that statin-dependent activation of HO-1 did not involve inhibition of HMG CoA reductase in ECV 304, a human cell line earlier described as an endothelial immortalized cell line and further characterized as a human bladder cancer cell line [34]. The gene discussed is HMOX1; the disease is urinary bladder carcinoma.