Inhibition of acto-myosin contractility using the myosin inhibitors, ML7 and BDM, induces reversible G0 arrest in C2C12 myoblasts [32] and induction of GAS1 and FOXO3a expression resulted in reduced proliferation in mouse fibroblasts and human colorectal carcinoma cells, respectively , , [71–73]. This evidence concerns the gene FOXO3 and colorectal carcinoma.