In the multivariate analysis, after adjusting for tumor grade and lymph node metastasis, only TRIM24 expression (hazard ratio, 1.910; 95% CI, 1.064-3.428; P = .030) and lymph node metastasis (hazard ratio, 2.837; 95% CI, 1.492-5.396; P = .018) were identified as independent factors contributing to the worse overall survival (Table 3). This evidence concerns the gene TRIM24 and metastatic malignant neoplasm in the lymph nodes.