A positive association was observed between the dual null genotype of GSTM1-GSTT1 and RCC risk in Asian populations; however, an inverse association was observed between the dual null genotype of GSTM1-GSTT1 and RCC risk in European populations, and we confirmed this result in the high-quality studies among European populations. Here, GSTM1 is linked to renal cell adenocarcinoma.