No association was found between the combined effects of GSTs polymorphisms and the susceptibility to RCC in most of the genetic models (Table 6, GSTM1(−)/GSTT1(−): OR = 1.06, 95% CI = 0.62–1.81; GSTM1(−)/GSTP1(−): OR = 1.51, 95% CI = 0.78–2.92; GSTM1(−)/GSTT1(−)/GSTP1(−): OR = 2.58, 95% CI = 0.78–8.53). The gene discussed is HPGDS; the disease is renal cell adenocarcinoma.