As for the subgroup analysis of populations in different geographic area, the heterogeneity was dramatically decreased in Asian populations (P>0.05), and a positive association was found between the GSTP1 polymorphisms and the susceptibility to RCC in most of the genetic models (dominant model: P<0.01, OR = 1.50, 95% CI = 1.14–1.99; additive model: P<0.01, OR = 1.39, 95% CI = 1.12–1.73; AG vs. AA: P = 0.01, OR = 1.47, 95% CI = 1.10–1.97; GG vs. AA: P = 0.03, OR = 1.82, 95% CI = 1.07– 3.09). This evidence concerns the gene GSTP1 and renal cell carcinoma.