Among the 113 genes up-regulated in both GCA and GNCA were genes associated with cell cycle checkpoint (eg, CDC2, TOP2A), Wnt signaling (eg, SULF1, SFRP4, LEF1, LAMB1), adhesion (eg, FN1), and the TGF-β pathway (eg, COL1A1, COL1A2, COL3A1). The gene discussed is LEF1; the disease is temporal arteritis.