A recent report of a case with multiple gastrointestinal neoplasias, including gastric adenocarcinomas, identified a germline homozygous intronic mutation in BUB1B, with low levels of BUB1B mRNA and protein in lymphocytes and fibroblasts, suggesting that BUB1B is a susceptibility gene for this tumor [40]. This evidence concerns the gene BUB1B and gastric adenocarcinoma.