Oral administration of quercetin in the last 6 weeks to insulin deficient animals did not affect the developed hyperglycaemia, serum insulin level and HOMA-IR but resulted in significant reduction of body weight (P<0.01), serum level of TNF-α (P<0.001) and serum CRP level (P<0.001) compared to insulin deficient group. This evidence concerns the gene TNF and Hyperglycemia.