APP and Cognitive impairment: Although we did not observe a significant decrease in the amount of immature neurons in the 12-month-old AβPP-PS1 mice in our current study, reduced hippocampal neurogenesis has been found previously in AβPP-PS1 mice [69]–[71] and in AD patients [72], [73], and might underlie some aspects of the cognitive deficits in AD.