CD8A and neoplasm: While our data show that arginine depletion has no negative impact on CD8+ T cell mediated cytotoxicity, others reported that peptide specific IFN-γ secretion and cytolytic activity as well as the tetanus-toxoid specific proliferation of MART-1 tumor antigen specific T cells can be inhibited by oxidative stress induced by MDSC of renal cell carcinoma patients [32].