HOTAIR and familial pancreatic carcinoma: Clinically, overexpression of HOTAIR is a powerful predictor of overall survival and progression for several cancers including pancreatic cancer [15], hepatocellular carcinoma [16], [17], colon cancer [18], nasopharyngeal carcinoma laryngeal [19], squamous cell carcinoma [20], breast cancer [21] and gastrointestinal stromal tumors [22].