HMGB1 and neoplasm: Thus, tight contact between DCs producing high levels of IL-12p70 and tumor cells expressing CRF, HMGB1, and HSP90α with inhibited production of immune-suppressive cytokines during the fusion process may act as essential recognition and danger/alarm signals to FCs, leading to increased fusion efficiency and function to induce efficient antigen-specific CTLs in vitro.