Although thttp://www.ncbi.nlm.nih.gov/pubmed/11948693he proapoptotic activity of Egr-1 may depend on the cell type and the nature of the stimulus, Egr-1-mediated apoptosis is associated with regulation of the expression of many tumor suppressor genes such as Egr-1 target genes [46]–[48]. This evidence concerns the gene EGR1 and neoplasm.