Of these, the four FGFR2 SNPs retained genome-wide significance level in subgroups with luminal A cases, cases with family history of breast cancer, low tumor grade and operable tumor stage while 8q24.21-rs13281615 and TNRC9-rs3803662 showed genome-wide significance level associations only in cases with low tumor grade and operable tumor stage, respectively. This evidence concerns the gene TOX3 and breast cancer.