PXN and cancer: We found that 4q31.22-rs1429142 is associated with differential expression of five other genes (quantitative transmission disequilibrium test P<0.0001, implemented in the SCAN database) involved in at least one type of cancer – i.e., kinesin family member 3B (KIF3B) [41], paxillin (PXN) [42], general transcription factor IIA, 12 kDa (GTF2A2) [43], PTPRF interacting protein, binding protein (liprin beta 2) (PPFIBP2) [44] and tumor protein p63 regulated 1-like (TPRG1L) [45].