ESR1 and breast cancer: Further, results from the subgroup analyses were consistent with the previous reports [33]–[35], supporting the hypothesis that FGFR2 loci (rs1219648, rs2420946 and rs2981582) are associated with increased risk of breast cancer, especially in familial breast cancer cases (Phet<0.02), and associated with the better prognosis luminal A type or estrogen receptor positive breast cancers (Phet<0.001) (Table S2) [33]–[35].