Tumor protein 53-induced nuclear protein 1 gene expression is often silenced in tumor cells due to oncogenic factors such as the micro RNAs miR-93, miR-130b, miR-155, miR-125b, miR-17-5p, and miR-17, which down-regulate TP53INP1 expression through post-transcriptional mechanisms. The gene discussed is TP53INP1; the disease is neoplasm.