In addition, injections of adenoviral vectors expressing small interfering (si)RNA targeting NOX2 (AdsiRNA-NOX2) or NOX4 (AdsiRNA-NOX4) mRNAs, used to knock down NOX2 and NOX4 proteins, in the PVN showed that either AdsiRNA-NOX2 or AdsiRNA-NOX4 significantly attenuated the development of Aldo/NaCl-induced hypertension (Xue et al., 2012). The gene discussed is NOX4; the disease is Hypertension.