Subsequently, it was shown that hypertension caused by Ang II infusion, but not norepinephrine infusion, increased vascular superoxide production in vivo (Rajagopalan et al., 1996) and that adenovirus-mediated superoxide dismutase (SOD) overexpression was effective in preventing this form of hypertension (Laursen et al., 1997; Zimmerman et al., 2004b; Davisson and Zimmerman, 2010; Lob et al., 2010). This evidence concerns the gene SOD1 and hypertensive disorder.