RUNX3 and multiple sclerosis: Table S8 shows that only the Immunochip loci showed a nominally significant (P = 0.001) excess of high-ranking BFs (those in the top 5% of the empirical distribution) of genes. We note that, other than the BET1L locus, the two highest ranking (in the top 0.1% of the empirical distribution) regions include the RUNX3 locus, implicated in ankylosing spondylitis [30] (empirical P = 0.0060) and the region containing the IL12A gene (empirical P = 0.0096) implicated in Celiac disease [31] and multiple sclerosis [31], [32].