Moreover, expression of UCHL1 was upregulated 2 days post-infection of HPV16 in primary keratinocytes when compared to mock-infected primary keratinocytes (Figure 4E), whereas knock-down of the polycistronic viral mRNA transcript in hrHPV+ KCs by siRNA for HPV16 E2 resulted in a decreased UCHL1 expression (Figure 4F). This evidence concerns the gene UCHL1 and infection.