NFKB1 and cancer: In addition, the loss of UCHL1 mediated suppression of the NF-κB pathway in hrHPV E6/E7-induced cancer cells fits well with the notion that solid tumors require the NF-κB-mediated expression of proteins that promote survival, proliferation, invasion and metastasis [48] which is acquired through the E6-mediated deactivation of CYLD [49], a negative regulator of TRAF2 and TRAF6-mediated activation of NF-κB [21], [24].