Although transformed keratinocytes expressing un-physiologically high levels of E6 and E7 via retroviral transduction still may express UCHL1, only a minority of spontaneously HPV-transformed cervical carcinoma's and none of the well known HPV-induced cancer cell lines overexpress UCHL1 [42], indicating that under normal conditions UCHL1 overexpression in HPV transformed cells is not a common event. Here, UCHL1 is linked to cancer.