Hypothetically, the existence of an HLA-C*0702-restricted HCMV epitope that mediates superior recognition of infection might be one of the factors that contribute to selection for the high frequency of this allotype in different human populations around the world [29], in whom it represents the most frequent HLA-C allotype with phenotypic frequencies of 30–40% [33], [72]. This evidence concerns the gene HLA-C and infection.