We also demonstrated that MSR1 functions in the induction of TLR3-mediated antiviral responses to HCV infection by monitoring viral replication in Huh7.5-TLR3/shNT cells and Huh7.5-TLR3/shMSR1 cells following infection with HJ3-5/GLuc2A virus [33] that expresses the secreted reporter protein, Gaussia princeps luciferase (GLuc). Here, TLR3 is linked to infection.