GLIPR1 and central nervous system cancer: Using a luciferase reporter plasmid in which the 3'-UTR of the RTVP-1 was cloned downstream of luciferase gene (pEZX-MT01:: RTVP-1-3'UTR), we demonstrated that miR-137 mimic significantly decreased the luciferase activity of this construct in U87 glioma cells by 4-fold as compared with a control miRNA (Figure 3D).