HTRA1 and age-related macular degeneration: Genome-wide association studies (GWAS) and candidate association studies have further contributed significantly in identifying the risk loci for AMD and have implicated genes—CFH15–19, C320, 21, C2-CFB22, CFI23, a region on chromosome 10 with HTRA1/LOC387715/ARMS224–26, CETP27, TIMP327, LIPC28, VEGFA29, COL10A129, TNFRSF10A30, and APOE31–33 with AMD (Table 1).