Subsequent sequencing revealed that roughly 36% of Lagatto Romagnolo dogs carry a point mutation in LGI2 that results in truncation of 11 amino acids from the C-terminus of the mutant LGI2 protein (Seppälä et al., 2011), indicating that LGI2, like LGI1, is an epilepsy gene. This evidence concerns the gene LGI2 and epilepsy.