Not all ADPEAF patients possess mutations in LGI1; the penetrance of ADPEAF in families that segregate LGI1 mutations is higher than in ADPEAF families without LGI1 mutations (Michelucci et al., 2013), suggesting that the disease has a complex and heterogeneous pattern of inheritance. Here, LGI1 is linked to autosomal dominant epilepsy with auditory features.