Both ADAM22 knockout and ADAM23 knockout mice show strong overlap in phenotype with LGI1 knockout mice, which is characterized by severe spontaneous epilepsy and premature death (Sagane et al., 2005; Owuor et al., 2009; Chabrol et al., 2010; Fukata et al., 2010; Yu et al., 2010). Here, LGI1 is linked to epilepsy.