LGI1 expression is reduced or absent in many glioma cell lines (Chernova et al., 1998; Krex et al., 2002; Rossi et al., 2005); it also has been reported to be down-regulated in glioma tumours (Besleaga et al., 2003), in Barrett’s-related adenocarcinoma of the esophagus (Peng et al., 2008), and in prostate cancer (Cowell et al., 2010). This evidence concerns the gene LGI1 and central nervous system cancer.