LGI1 and central nervous system cancer: In contrast, co-expression of a neuronal marker and LGI1 in gliomas suggests that LGI1 expression levels in these tumours may relate to the number of trapped neurons (Piepoli et al., 2006), and ADPEAF patients do not show increased frequencies of glioma (Brodtkorb et al., 2003; Gu et al., 2005a).