CNR1 and steatosis: Indeed, the finding that THCV is able to reduce liver triglyceride levels is unsurprising as activation of hepatic CB1 receptor is instead sufficient for the development of diet-induced steatosis, dyslipidaemia and insulin resistance in mice.21 More recently, selective CB1 activation in hepatocytes was reported to cause hepatic insulin resistance,22 and, accordingly, we have shown here that THCV instead restores insulin sensitivity in these cells after that they were rendered insulin-resistant.