We also observed a significant correlation between antigenic levels of PAI-1 and DA (r = 0.739, p = 0.009) and ES levels (r = 0.640, p = 0.034) in patients with active disease (DA > 0), which implicates PAI-1 as a potential link between vasculitis and/or the inflammatory state and enhanced clot formation in BD patients. The gene discussed is SERPINE1; the disease is vasculitis.