A large number of  T2D genes found via GWAS are involved in cell cycle regulation [34], for example, the T2D association SNP mapping to chromosome 9p21 in the vicinity of the tumour suppressor genes CDKN2A and CDKN2B [130–132] and the CDKN2B regulator ANRIL [133–135]. Here, CDKN2B-AS1 is linked to type 2 diabetes mellitus.