4.5. The Levels of RANKL, OPG, RANKL/OPG, TNF-α, IL-6 and IL-17 in the PBMCs Culture Supernatant of RA Patients and Healthy Control after Cotreatment with 1,25(OH)2D3 and MTX. The gene discussed is TNFRSF11B; the disease is rheumatoid arthritis.