The treatment of 1,25(OH)2D3 had no significant effect on the levels of OPG, RANKL/OPG and IL-4 compared to anti-CD3/CD28 group in RA patients (P > 0.05; Table 4; Figures 5, 6, and 7). The gene discussed is TNFRSF11B; the disease is rheumatoid arthritis.