This adds not only to our understanding of cardiovascular disease susceptibility for Hp2-2 but may also be relevant to the protection of the vasculature and kidneys from heme-mediated oxidative injury secondary to hemolysis [32–35], especially in predisposing conditions like diabetes, sickle cell anemia, or leukaemia treatment [16, 36, 37]. Here, ARL6IP5 is linked to sickle cell disease.