In conclusion, our finding of an association between a myeloid clonal proliferation with t(7;12)(q22;p13), ETV6 rearrangement, and eosinophilia in a patient previously diagnosed with LBL is in agreement with the findings of other authors [6–8] and supports the diagnosis of a hematopoietic neoplasm originating in very immature cells with the ability to differentiate in myeloid and lymphoid lineages at different moments. The gene discussed is ETV6; the disease is hematopoietic and lymphoid cell neoplasm.