Furthermore, patients with a Day 100 ALC/AMC < 1.3 tended to have adverse features at diagnosis including high tumor burden (bulky disease), low albumin, high WBC, lymphopenia, male gender, higher IPS index, and low Day 15 ALC, suggesting the impact of host immunity (i.e., ALC) versus tumor micro-environment (i.e., AMC) on tumor growth control. The gene discussed is ALB; the disease is lymphopenia.