The findings of our previous study that male Nrf2-KO mice were at least partially protected from HFD-induced (60 kcal% fat) obesity and were more insulin sensitive and more glucose tolerant compared to their WT counterparts [13] are consistent with previous reports using comparable but different treatment parameters (40 kcal% fat diet or modified high-fat-diets) [14–16]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.