TRPV1 and diabetic neuropathy: Indeed, further studies are necessary to clarify: (i) if the effects of STZ and EA on MAPKs and TRPV1 are only mediated by NGF signaling modulation or if other signaling systems are involved; (ii) if neurobehavioural features other than thermal hyperalgesia known to be altered in late diabetic neuropathy and affected by NGF—that is, decreased motor and sensory nerve conduction velocity [35] or increased mechanical sensitivity [36]—would have been affected in our experimental model.