PFTs can also elicit and alter apoptosis of host immune cells, that is, AFT via caspase-2 [154, 155], leukocidins via activation of caspases 3 and 9 [156], LLO via release of cytochrome C from mitochondria [157], β-hemolysin/cytolysin independently of caspase activation [36, 39], HlyA [158], and ClyA [159], thus potentially contributing to the apparent immunodeficiency of the patient that is characteristic during stages of sepsis [160]. This evidence concerns the gene PRF1 and Sepsis.