PRF1 and Sepsis: However, PFTs may also contribute to sepsis by receptor mediated or membrane damaging mechanisms in immune cells, which respond with the formation of inflammatory mediators, as was shown for β-hemolysin/cytolysin from GBS [28] and listeriolysin O [29, 30] and α-hemolysin and Panton-Valentine leukocidins from S. aureus [31, 32].