These cells are T lymphocytes: tumor cell-derived IL-6, interleukin-1 (IL-1), and TGF-β can drive T-cell differentiation towards a Th17 secretory helper-cell phenotype capable of inducing RANKL production by OBs and OC activation through interleukin-17 (IL-17) production (Figure 1) [42]. Here, TGFB1 is linked to neoplasm.