GPT and toxicity: Drug-related adverse events of severe liver toxicity are defined by Grade 3 (>5.0–20.0× ULN) or Grade 4 (≥20× ULN) elevations in alanine transaminase (ALT) or aspartate transaminase (AST), or Grade 3 (>3.0–10.0× ULN) or Grade 4 (>10.0× ULN) elevations for total bilirubin (BILI) [4].