However, there are differences between LADA, as recently defined by the Immunology of Diabetes Society, and A+ β+ KPD patients; most importantly, the definition of LADA excludes patients who require insulin within the first 6 months after diagnosis, whereas the majority (90%) of A+ β+ KPD patients present with DKA as the first manifestation of diabetes and therefore require insulin at the start [32, 33]. The gene discussed is INS; the disease is diabetes mellitus.