To demonstrate the role of Wnt/β-catenin canonical pathway in postmenopausal osteoporosis, we evaluated the levels of serum β-catenin, OPG, RANKL, sclerostin, and bone turnover markers in postmenopausal osteoporotic patients and compared them to those in postmenopausal nonosteoporotic women. This evidence concerns the gene TNFRSF11B and postmenopausal osteoporosis.