AFP and hepatocellular carcinoma: Univariate analysis identified the following factors as significantly associated with OS for all cases (n = 233): HCC stage (P < 0.001), maximum tumor size > 3.5 cm (P = 0.016), tumor number (P = 0.005), interferon (IFN) therapy after surgery (P = 0.039), ICGR 15 > 13.5% (P = 0.038), serum albumin > 3.8 g/dL (P < 0.001); AFP > 20 ng/mL (P < 0.001), and microscopic vascular invasion (P < 0.001) (Table 2).