JAK2 and cancer: The detailed mechanism of CTXIII-induced apoptosis have well demonstrated, such as mitochondrial alteration, reactive oxygen species generation of neuroblastoma SK-N-SH cells [23], NF-κB inactivation in breast MCF-7 cancer cells [12], and downregulation of the JAK2/PI3K signaling in breast MDA-MB-231 cancer cells [24].