TP53 and oropharynx squamous cell carcinoma: Although we did not clearly identify the downstream signals and role of STAT1, our data suggest that activated STAT1 and interferon signals by HPV16 E6 and E7 may play a major role in the relatively favorable prognosis for patients with a non-disruptive p53 mutation, HPV-positive oropharyngeal squamous cell carcinomas.