Experiments were also performed using an HOX11 expression construct, since HOX11 represents a T-ALL oncogenic homeobox gene whose high expression constitutes an independent patient group without elevated LMO2 expression (see Figure 3a).13, 14, 19 Transactivation assays performed with HOX11, HOXA7 or HOXA9 did not show significant enhancement of luciferase activity, even in the presence of their dimerization partner Meis1 (data not shown). The gene discussed is MEIS1; the disease is acute lymphoblastic leukemia.