Moreover, T-ALL samples with an HOXA signature and high LMO2 commonly display an immature ETP phenotype13, 17, 19, 21 and occasionally co-express both lymphoid and myeloid surface antigens.13, 22 However, T-ALL samples with translocations involving the LMO2 locus generally present a more mature phenotype.13, 17 Moreover, the HOXA-inducing MLL or CALM-AF10 translocations are also often found in T-ALL patients with immature T-cell immunophenotypes,13, 14, 22, 23 thus suggesting a common theme of HOXA-LMO2 activation in this subgroup of T-ALL. This evidence concerns the gene LMO2 and acute lymphoblastic leukemia.