LMO2 and acute myeloid leukemia: Lethally irradiated mice transplanted with MLL-ENL immortalized bone marrow progenitors develop AML following a latency period of an average of 90–100 days, with leukaemic cells expressing the myeloid surface markers Mac-1 and Gr-1 as well as Lmo2. 28 We hypothesized that maintenance of high Lmo2 levels could be important for the ability of these cells to cause AML in vivo.