LMO2 and acute lymphoblastic leukemia: First, we have recently reported LMO2 upregulation in the evolution of leukaemia stem cell activity and disease generation in a mouse model of AML.38 Second, retroviral integration screens for the identification of new contributors to leukaemia development have reported integration into the murine LMO2 locus not only in T-ALL but also in B-ALL and AML (RTCGD database), with all translocations occurring 5′ of the LMO2 coding region and thus presumably enhancing its expression.