TLX3 and acute lymphoblastic leukemia: To this end, we analysed LMO2 expression in a published cohort of 67 T-ALL patients, grouped into 5 clusters largely based on their primary cytogenetic abnormality (TAL1, LMO2, HOX11, HOX11L2 and HOXA).14LMO2 expression was highest in those samples with LMO2 and TAL1 translocations, which are known to represent a T-ALL subgroup with similar genetic and phenotypic characteristics13, 14, 17 but was also elevated in patients with upregulation of HOXA locus genes (Figure 3a).