To this end, we analysed LMO2 expression in a published cohort of 67 T-ALL patients, grouped into 5 clusters largely based on their primary cytogenetic abnormality (TAL1, LMO2, HOX11, HOX11L2 and HOXA).14LMO2 expression was highest in those samples with LMO2 and TAL1 translocations, which are known to represent a T-ALL subgroup with similar genetic and phenotypic characteristics13, 14, 17 but was also elevated in patients with upregulation of HOXA locus genes (Figure 3a). This evidence concerns the gene HOXA7 and acute lymphoblastic leukemia.