LMO2 and leukemia: In cell culture under cytokine-mediated self-renewal conditions, high Lmo2 levels were associated with a proliferative advantage, and therefore correlated with the hyperproliferation/self-renewal phenotype reported by McCormack et al.37 in T-cell progenitors ectopically expressing high levels of Lmo2. Reducing Lmo2 levels did not however affect latency of leukaemia onset in an adoptive transfer setting, suggesting that elevated Lmo2 levels may be dispensable, or that other mutations may compensate for their loss in the context of this particular assay.