SOD1 and Alzheimer disease: Our previous studies demonstrated that Sod1-deficient (Sod1−/−) mice show various aging-like pathologies, such as: age-related macular degeneration [6], fatty deposits in the liver [7], skin atrophy [8], osteoporosis [9], deterioration of Alzheimer’s disease (AD) [10], luteal degeneration [11], and lacrimal degeneration [12].