The PIK3CA, PTEN and TP53 genes were already well known to be involved in the tumorigenesis of PCa, but several genes not previously known to undergo somatic alteration in PCa were enriched for mutations, including FOXA1, MED12, THSD7B, SCN11A, NIPA2, C14orf49 and ZNF595 [58]. Here, SYNE3 is linked to posterior cortical atrophy.