Barbieri and colleagues reported twelve genes, which were recurrently mutated and contained more mutations in PCa than expected by chance: PIK3CA, PTEN, TP53, SPOP, FOXA1, MED12, CDKN1B, ZNF595, THSD7B, NIPA2, C14orf49 and SCN11A (Figure 1) [58]. This evidence concerns the gene PIK3CA and posterior cortical atrophy.