At the molecular level,beta-2-microglobulin (B2M), CDH1, ZEB1,ZEB2, ATRX, HFE and themiR-200s are involved in genetic disorders; B2M,transferrin receptor 2 (TFR2), HFEand angiotensin II receptor (AGTR1) are involved in metabolic diseases;B2M, E2F, miR-200s,ATRX, DLC1, ZEB1,ZEB2, CDH1 and caveolin 1 (CAV1) areinvolved in cancer (Table V). This evidence concerns the gene TFR2 and metabolic disease.