DICER1 and cancer: Although, thechanges in the expression of these genes at the mRNA and protein levels after re-expressionof miR-200s in H1299 cells were relatively small (<2-fold), such small changes inthe expression of microRNA targets are very common (16,53).Despite restoration of normal miR-200 levels, some other components of thepost-transcriptional gene silencing pathway in H1299 cells might be in limiting amounts, forexample Dicer, which is commonly downregulated in cancer cells (54).