In the present study,re-expression of miR-200a, -200b or -200c in metastatic human NSCLC cells resulted inDLC1 downregulation at both mRNA and protein expression levels, withmiR-200a exerting the most significant repression of DLC1. Theoverexpression of miR-200 family observed in primary tumors (Fig. 1B) could downregulate DLC1, which is involvedin tumorigenesis (Fig. 6).Downregulation of DLC1, in turn, is associated with poor prognosis of NSCLC(21). Here, DLC1 is linked to non-small cell lung carcinoma.