HFE polymorphism is associated with multiplecancer types and chemoresponse (56).The complex of beta-2-microglobulin (B2M) and its receptor HFE activatesEMT and promotes metastases in human prostate, breast, lung and renal cancer cells bothin vivo and in vitro, through the modulation of ironresponsive pathways (57). This evidence concerns the gene B2M and renal carcinoma.