The findings of the miR-200 downregulationof DLC1, ATRX, HNRPNA3,AHNAK and HFE in metastatic human NSCLC cells and theproposed regulatory mechanisms in tumorigenesis and metastasis could provide the basis forthe development of novel therapeutic approaches for the treatment of this deadly disease. The gene discussed is DLC1; the disease is non-small cell lung carcinoma.